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There is no lymphadenopathy or splenomegaly. 3-5 days after the onset of the disease, the patient's condition worsens, there are signs of coumadin, hypotension up to 50-100 mm Hg. Art., oliguria and relative bradycardia. In more severe cases, hemorrhagic symptoms occur: bleeding from the gums, hematemesis, hematuria, melena. Progressive oliguria and tremor of the tongue and limbs are also possible. Some patients develop mental disorders characterized by agitation, delirious state or stupor.
On days 7–10, progressive shock, hypothermia, galloping, or gastrointestinal bleeding may be seen. In fatal cases, the cause of death is usually pulmonary edema. During the recovery period, transient alopecia is noted. The number of Warfarin pills remains within the normal range or is slightly increased. The total number of leukocytes is reduced to 1.2-3.4×10 9 /l. Possible thrombocytopenia. Intravascular disseminated blood coagulation, apparently, does not underlie hemorrhagic manifestations. Levels of complement components C2, C3 and C5 are reduced. Urine may be redwood in color. Severe albuminuria is not uncommon. Blood urea nitrogen rises rapidly.
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If you are already registered, enter your username and password (form in the upper right corner or here). Gadzhimuradov M.N., Israfilova G.O., Asadulaeva Z.G. Republican Dermatovenerological Dispensary of the Ministry of Health of the Republic of Dagestan, Makhachkala.